STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

Spontaneous CD8 T-cell responses occur in growing tumors but are usually poorly effective. Understanding the molecular and cellular mechanisms that drive these responses is of major interest as they could be exploited to generate a more efficacious antitumor immunity. As such, stimulator of IFN genes (STING), an adaptor molecule involved in cytosolic DNA sensing, is required for the induction of antitumor CD8 T responses in mouse models of cancer. Here, we find that enforced activation of STING by intratumoral injection of cyclic dinucleotide GMP-AMP (cGAMP), potently enhanced antitumor CD8 T responses leading to growth control of injected and contralateral tumors in mouse models of melanoma and colon cancer.…

• YU
  Yale University
• LI
  Ludwig Institute for Cancer Research
• IN
  Institut National de la Santé et de la Recherche Médicale

  Award: U1065
• O
  Oncosuisse

  Award: KLS-3161-02-2013
• NC
  National Cancer Institute

  Award: PO1 CA128913