Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

Inflammasome is an intracellular signaling complex of the innate immune system. Activation of inflammasomes promotes the secretion of interleukin 1β (IL-1β) and IL-18 and triggers pyroptosis. Caspase-1 and -11 (or -4/5 in human) in the canonical and non-canonical inflammasome pathways, respectively, are crucial for inflammasome-mediated inflammatory responses. Here we report that gasdermin D (GSDMD) is another crucial component of inflammasomes. We discovered the presence of GSDMD protein in nigericin-induced NLRP3 inflammasomes by a quantitative mass spectrometry-based analysis. Gene deletion of GSDMD demonstrated that GSDMD is required for pyroptosis and for the secretion but not proteolytic maturation of…

• NS
  National Science Foundation
• NN
  National Natural Science Foundation of China

  Awards: 2015CB553800, 31420103910, J1310027, 31221065, 31330047, 91429301, B12001
• XU
  Xiamen University
• HE
  Higher Education Discipline Innovation Project

  Award: B12001
• NH
  National High-tech Research and Development Program

  Award: 2012AA02A201
• NK
  National Key Research and Development Program of China

  Awards: 2015CB553800, 31221065