Germline Mutations in HOXB13 and Prostate-Cancer Risk
Johns Hopkins University · Johns Hopkins Hospital · +6 more institutions
Abstract
Family history is a significant risk factor for prostate cancer, although the molecular basis for this association is poorly understood. Linkage studies have implicated chromosome 17q21-22 as a possible location of a prostate-cancer susceptibility gene.
We screened more than 200 genes in the 17q21-22 region by sequencing germline DNA from 94 unrelated patients with prostate cancer from families selected for linkage to the candidate region. We tested family members, additional case subjects, and control subjects to characterize the frequency of the identified mutations.
Citation impact
- FWCI
- 43.79
- Percentile
- 100%
- References
- 35
Authors
25- CMCharles M. EwingCorresponding
Johns Hopkins University, Johns Hopkins Hospital
- AMAnna M. Ray
University of Michigan, U-M Rogel Cancer Center
- EMEthan M. Lange
UNC Lineberger Comprehensive Cancer Center
- KAKimberly A. Zuhlke
University of Michigan, U-M Rogel Cancer Center
- CMChristiane M. Robbins
Translational Genomics Research Institute
Topics & keywords
- Prostate cancer
- Medicine
- Germline mutation
- Prostate
- Proband
- Cancer
- Oncology
- Germline
- Good health and well-being