Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer
BGI Group (China) · University of Copenhagen · +10 more institutions
Abstract
To evaluate the potential for diagnosing colorectal cancer (CRC) from faecal metagenomes.
We performed metagenome-wide association studies on faecal samples from 74 patients with CRC and 54 controls from China, and validated the results in 16 patients and 24 controls from Denmark. We further validated the biomarkers in two published cohorts from France and Austria. Finally, we employed targeted quantitative PCR (qPCR) assays to evaluate diagnostic potential of selected biomarkers in an independent Chinese cohort of 47 patients and 109 controls.
Citation impact
- FWCI
- 18.67
- Percentile
- 100%
- References
- 46
Authors
41- JYJun Yu
BGI Group (China), University of Copenhagen, Chinese University of Hong Kong, Chinese University of Hong Kong, Shenzhen, Qi2
- QFQiang Feng
BGI Group (China), University of Copenhagen
- SHSunny H. Wong
BGI Group (China), University of Copenhagen, Chinese University of Hong Kong, Chinese University of Hong Kong, Shenzhen, Qi2
- DZDongya Zhang
BGI Group (China)
- QYQiao yi Liang
BGI Group (China), University of Copenhagen, Chinese University of Hong Kong, Chinese University of Hong Kong, Shenzhen, Qi2
Topics & keywords
- Metagenomics
- Microbiome
- Colorectal cancer
- Medicine
- Cancer
- Gut microbiome
- Computational biology
- Biology