Principles of connectivity among morphologically defined cell types in adult neocortex
Baylor College of Medicine · Bernstein Center for Computational Neuroscience Tübingen · +2 more institutions
Abstract
Since the work of Ramón y Cajal in the late 19th and early 20th centuries, neuroscientists have speculated that a complete understanding of neuronal cell types and their connections is key to explaining complex brain functions. However, a complete census of the constituent cell types and their wiring diagram in mature neocortex remains elusive. By combining octuple whole-cell recordings with an optimized avidin-biotin-peroxidase staining technique, we carried out a morphological and electrophysiological census of neuronal types in layers 1, 2/3, and 5 of mature neocortex and mapped the connectivity between more than 11,000 pairs of identified neurons. We categorized 15 types of interneurons, and each exhibited…
Citation impact
- FWCI
- 36.21
- Percentile
- 100%
- References
- 69
Authors
8- XJXiaolong JiangCorresponding
Baylor College of Medicine
- SSShan Shen
Baylor College of Medicine
- CRCathryn R. Cadwell
Baylor College of Medicine
- PBPhilipp Berens
Baylor College of Medicine, Bernstein Center for Computational Neuroscience Tübingen, University of Tübingen
- FHFabian H. Sinz
Baylor College of Medicine
Topics & keywords
- Neocortex
- Biology
- Evolutionary biology
- Neuroscience