Comprehensive molecular profiling of lung adenocarcinoma

Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen (mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually exclusive with focal MYC amplification. EGFR mutations were more frequent in female patients, whereas mutations in RBM10 were more common in males. Aberrations in NF1, MET, ERBB2 and RIT1 occurred in 13% of cases and…

• NI
  National Institutes of Health

  Awards: U24 CA143882, U54 HG003079, U24 CA143866, U54 HG003067, U24 CA143799, CA143835, U24 CA143835, U24 CA143843, U24 CA144025, HG003079, U54 HG003273, CA143883, U24 CA143845, U24 CA143848, U24 CA143858, HG003067, U24 CA143883, U24 CA143840, U24 CA143867
• NC
  National Cancer Institute

  Awards: U24 CA143799, U24 CA143835, U24 CA143867, U54 HG003273, U54 HG003067, U24 CA143866, U24 CA143845, CA143883, U24 CA143883, U24 CA143848, U24 CA143858, U24 CA144025, U24 CA143843, U24 CA143840, CA143840, U24 CA143882, U54 HG003079