The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four…

• NS
  National Science Foundation

  Awards: 33CS30-139468, 33CS30-148401, 33CSCO-122661
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  U.S. Department of Veterans Affairs

  Awards: 10-000-1002, P30 DK072488
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  Susan G. Komen for the Cure
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  John D. and Catherine T. MacArthur Foundation
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  Juvenile Diabetes Research Foundation International

  Award: 068545/Z/02
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  March of Dimes Foundation
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  Illinois Department of Public Health
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  Office of Research and Development
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  Velux Stiftung
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  Torsten Söderbergs Stiftelse
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  Universitetet i Tromsø
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  Johns Hopkins University

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  Helsingin ja Uudenmaan Sairaanhoitopiiri

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  Yrjö Jahnssonin Säätiö
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  Aarne Koskelon Säätiö
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  Wellcome Trust

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  Translational Genomics Research Institute
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  National Institute for Health and Care Research
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  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

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• UL
  Universiteit Leiden

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  Rijksuniversiteit Groningen

  Award: 10-000-1002
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  ZonMw

  Awards: 985-10-002, GB-MW 940-38-011, 10-000-1002, 261-98-710, 175.010.2003.005, 175.010.2007.006, Addiction-31160008, 56-464-14192, 904-61-193, 400-05-717, 100-001-004, 904-61-090, 60-60600-97-118, 91111025, 31160008, 480-04-004, 050-060-810
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  Vrije Universiteit Amsterdam
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  Russian Foundation for Basic Research

  Awards: 047.017.043, NWO-RFBR 047.017.043
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  Kela
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  Academy of Finland

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  Bundesministerium für Bildung und Forschung

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  Cancerfonden
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  Ministero della Salute

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  Nederlandse Organisatie voor Wetenschappelijk Onderzoek

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  Tekes

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  Ministero dell’Istruzione, dell’Università e della Ricerca
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  Svenska Sällskapet för Medicinsk Forskning
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  Hjärt-Lungfonden

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  Juho Vainion Säätiö
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  Karolinska Institutet
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  Knut och Alice Wallenbergs Stiftelse
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  Kuopion Yliopistollinen Sairaala
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  Novo Nordisk
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  Päivikki ja Sakari Sohlbergin Säätiö
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  Stockholms Läns Landsting

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  Vetenskapsrådet

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  KWF Kankerbestrijding
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  Samfundet Folkhälsan
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  Leids Universitair Medisch Centrum
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  Universitair Medisch Centrum Groningen
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  Region Hovedstaden
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  Norges Forskningsråd
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  Oulun Yliopisto

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  Fondation Leenaards
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  Tampereen Tuberkuloosisäätiö
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  Medical Research Council Canada

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  Svenska Kulturfonden
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  Tartu Ülikool

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  Paavo Nurmen Säätiö
• CS
  Chinese Society of Clinical Oncology
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  Turun Yliopistollinen Keskussairaala

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  SystemsX.ch

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  Fondation Institut de Cardiologie de Montréal
• ID
  Institut de Cardiologie de Montréal
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  Hjartavernd
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  Fondation contre le Cancer
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  Provincia autonoma di Bolzano - Alto Adige
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  Medical Research Council

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  National Health and Medical Research Council

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  Helmholtz Zentrum München
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  Netherlands Heart Institute
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  Münchner Zentrum für Gesundheitswissenschaften
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  NIHR Cambridge Biomedical Research Centre
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  Biocenter, University of Oulu
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  National Institute of Mental Health

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  NIH Clinical Center
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  Interreg