VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires
Institute of Bioorganic Chemistry · Pirogov Russian National Research Medical University · +4 more institutions
Abstract
Despite the growing number of immune repertoire sequencing studies, the field still lacks software for analysis and comprehension of this high-dimensional data. Here we report VDJtools, a complementary software suite that solves a wide range of T cell receptor (TCR) repertoires post-analysis tasks, provides a detailed tabular output and publication-ready graphics, and is built on top of a flexible API. Using TCR datasets for a large cohort of unrelated healthy donors, twins, and multiple sclerosis patients we demonstrate that VDJtools greatly facilitates the analysis and leads to sound biological conclusions. VDJtools software and documentation are available at https://github.com/mikessh/vdjtools.
Citation impact
- FWCI
- 11.66
- Percentile
- 100%
- References
- 66
Authors
13- MSMikhail Shugay
Institute of Bioorganic Chemistry, Pirogov Russian National Research Medical University
- DVDmitriy V. Bagaev
Institute of Bioorganic Chemistry
- MAMaria A. Turchaninova
Pirogov Russian National Research Medical University, Institute of Bioorganic Chemistry
- DADmitriy A. Bolotin
Institute of Bioorganic Chemistry, Pirogov Russian National Research Medical University
- OVOlga V. Britanova
Institute of Bioorganic Chemistry, Central European Institute of Technology – Masaryk University, Pirogov Russian National Research Medical University, Central European Institute of Technology
Topics & keywords
- T-cell receptor
- Repertoire
- Software
- Computer science
- Documentation
- Computational biology
- Graphics
- Suite