reviewAging CellDec 8, 2015GOLD OA

Long live FOXO : unraveling the role of FOXO proteins in aging and longevity

RMRute MartinsGJGordon J. LithgowWLWolfgang Link

University of Algarve · Buck Institute for Research on Aging

PubMed
Indexed incrossrefdoajpubmed

Abstract

Aging constitutes the key risk factor for age-related diseases such as cancer and cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are complex phenotypes influenced by both environmental and genetic factors. The fact that genetic contribution to lifespan strongly increases with greater age provides basis for research on which "protective genes" are carried by long-lived individuals. Studies have consistently revealed FOXO (Forkhead box O) transcription factors as important determinants in aging and longevity. FOXO proteins represent a subfamily of transcription factors conserved from Caenorhabditis elegans to mammals that act as key regulators of longevity downstream of insulin…

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715
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Authors

3

Topics & keywords

Topics
Keywords
  • Longevity
  • Biology
  • FOXO3
  • Caenorhabditis elegans
  • Transcription factor
  • FOXO1
  • Forkhead Transcription Factors
  • Subfamily
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