Osteoimmunomodulation for the development of advanced bone biomaterials
Queensland University of Technology · Shanghai Institute of Ceramics · +1 more institution
Abstract
As direct effector cells for osteogenesis, osteoblastic cells are commonly used for evaluating the in vitro osteogenic capacity of bone biomaterials, and the traditional biological principle for developing bone biomaterials is to directly stimulate osteogenic differentiation. With this principle, most efforts are currently spent on optimizing the bio-mechanical and physicochemical properties to induce osteogenic differentiation of mesenchymal stem cells. This strategy has achieved certain success in the development of bone biomaterials; however, inconsistencies between in vitro and in vivo studies are not uncommon, implying the mechanisms that govern the material's capacity to mediate osteogenesis is not…
Citation impact
- FWCI
- 15.82
- Percentile
- 100%
- References
- 195
Authors
7- ZCZetao Chen
Queensland University of Technology
- TJTravis J. Klein
Queensland University of Technology
- RZRachael Z. Murray
Queensland University of Technology
- RCRoss Crawford
Queensland University of Technology
- JCJiang Chang
Queensland University of Technology, Shanghai Institute of Ceramics, Chinese Academy of Sciences
Topics & keywords
- Osteoimmunology
- Biomaterial
- Mesenchymal stem cell
- In vivo
- Biomedical engineering
- Nanotechnology
- Materials science
- Cell biology