Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression
Emory University · Georgia Institute of Technology · +2 more institutions
Abstract
Depression is associated with alterations in corticostriatal reward circuitry. One pathophysiological pathway that may drive these changes is inflammation. Biomarkers of inflammation (for example, cytokines and C-reactive protein (CRP)) are reliably elevated in depressed patients. Moreover, administration of inflammatory stimuli reduces neural activity and dopamine release in reward-related brain regions in association with reduced motivation and anhedonia. Accordingly, we examined whether increased inflammation in depression affects corticostriatal reward circuitry to lead to deficits in motivation and goal-directed motor behavior. Resting-state functional magnetic resonance imaging was conducted on 48…
Citation impact
- FWCI
- 11.25
- Percentile
- 100%
- References
- 76
Authors
7Topics & keywords
- Anhedonia
- Psychology
- Ventral striatum
- Ventromedial prefrontal cortex
- Neuroscience
- Striatum
- Functional magnetic resonance imaging
- Nucleus accumbens
- Good health and well-being