articleThe Journal of Clinical Endocrinology & MetabolismDec 29, 2015Closed access

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

FCFrancesca CintiRBRyotaro BouchiJYJa Young Kim-MullerYOYoshiaki OhmuraPRP. Rodrigo Sandoval

Marche Polytechnic University · Columbia University · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Objective

To determine whether similar processes occur in human type 2 diabetes, we surveyed pancreatic islets from 15 diabetic and 15 nondiabetic organ donors.

Design

We scored dedifferentiation using markers of endocrine lineage, β-cell-specific transcription factors, and a newly identified endocrine progenitor cell marker, aldehyde dehydrogenase 1A3.

Citation impact

539
total citations
FWCI
31.92
Percentile
100%
References
49
Citations per year

Authors

11

Topics & keywords

Topics
Keywords
  • Progenitor cell
  • Enteroendocrine cell
  • Glucagon
  • Endocrine system
  • Diabetes mellitus
  • Endocrinology
  • Internal medicine
  • Type 2 diabetes
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.