BiGG Models: A platform for integrating, standardizing and sharing genome-scale models

Genome-scale metabolic models are mathematically-structured knowledge bases that can be used to predict metabolic pathway usage and growth phenotypes. Furthermore, they can generate and test hypotheses when integrated with experimental data. To maximize the value of these models, centralized repositories of high-quality models must be established, models must adhere to established standards and model components must be linked to relevant databases. Tools for model visualization further enhance their utility. To meet these needs, we present BiGG Models (http://bigg.ucsd.edu), a completely redesigned Biochemical, Genetic and Genomic knowledge base. BiGG Models contains more than 75 high-quality, manually-curated…

• NS
  National Science Foundation
• UD
  U.S. Department of Energy
• EC
  European Commission
• NN
  Novo Nordisk
• DT
  Danmarks Tekniske Universitet
• NI
  National Institutes of Health