Sestrin2 is a leucine sensor for the mTORC1 pathway
Broad Institute · Howard Hughes Medical Institute · +3 more institutions
Abstract
From sensing leucine to metabolic control The mTORC1 protein kinase complex plays central roles in regulating cell growth and metabolism and is implicated in common human diseases such as diabetes and cancer. The level of the amino acid leucine tells an organism a lot about its physiological state, including how much food is available, how much insulin is going to be needed, and whether new muscle mass can be made (see the Perspective by Buel and Blenis). Wolfson et al. identified a biochemical sensor of leucine, Sestrin2, which connects the concentration of leucine to the control of organismal metabolism and growth. When leucine bound to Sestrin2, it was released from a complex with the mTORC1 regulatory…
Citation impact
- FWCI
- 43.06
- Percentile
- 100%
- References
- 47
Authors
7- RLRachel L. WolfsonCorresponding
Broad Institute, Howard Hughes Medical Institute, Allen Institute, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
- LCLynne ChantranupongCorresponding
Broad Institute, Howard Hughes Medical Institute, Allen Institute, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
- RARobert A. Saxton
Broad Institute, Howard Hughes Medical Institute, Allen Institute, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
- KSKuang Shen
Broad Institute, Howard Hughes Medical Institute, Allen Institute, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
- SMSonia M. Scaria
Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
Topics & keywords
- mTORC1
- Leucine
- Biochemistry
- Amino acid
- Biology
- Function (biology)
- Metabolism
- Cell biology