Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

Schneeberger, Marc; Everard, Amandine; Gómez-Valadés, Alícia G.; Matamoros, Sébastien; Ramírez, Sara; Delzenne, Nathalie M.; Gomis, Ramón; Claret, Marc; Cani, Patrice D.

doi:10.1038/srep16643

articleScientific ReportsNov 13, 2015GOLD OA

Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

MSMarc Schneeberger AEAmandine Everard AGAlícia G. Gómez-Valadés SMSébastien Matamoros SRSara Ramírez

Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · +2 more institutions

PubMed

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Abstract

Recent evidence indicates that the gut microbiota plays a key role in the pathophysiology of obesity. Indeed, diet-induced obesity (DIO) has been associated to substantial changes in gut microbiota composition in rodent models. In the context of obesity, enhanced adiposity is accompanied by low-grade inflammation of this tissue but the exact link with gut microbial community remains unknown. In this report, we studied the consequences of high-fat diet (HFD) administration on metabolic parameters and gut microbiota composition over different periods of time. We found that Akkermansia muciniphila abundance was strongly and negatively affected by age and HFD feeding and to a lower extend Bilophila wadsworthia was…

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Keywords

Akkermansia muciniphila
Gut flora
Akkermansia
Adipose tissue
Biology
Endocrinology
Internal medicine
Inflammation

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