Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder
University of Nevada, Reno · Chinese Academy of Sciences · +4 more institutions
Abstract
Increasing evidence indicates that metabolic disorders in offspring can result from the father's diet, but the mechanism remains unclear. In a paternal mouse model given a high-fat diet (HFD), we showed that a subset of sperm transfer RNA-derived small RNAs (tsRNAs), mainly from 5' transfer RNA halves and ranging in size from 30 to 34 nucleotides, exhibited changes in expression profiles and RNA modifications. Injection of sperm tsRNA fractions from HFD males into normal zygotes generated metabolic disorders in the F1 offspring and altered gene expression of metabolic pathways in early embryos and islets of F1 offspring, which was unrelated to DNA methylation at CpG-enriched regions. Hence, sperm tsRNAs…
Citation impact
- FWCI
- 75.38
- Percentile
- 100%
- References
- 39
Authors
16- QCQi ChenCorresponding
University of Nevada, Reno, Chinese Academy of Sciences, Institute of Zoology
- MYMenghong YanCorresponding
Shanghai Institutes for Biological Sciences
- ZCZhonghong CaoCorresponding
Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Zoology
- XLXin LiCorresponding
Chinese Academy of Sciences, Institute of Zoology
- YZYunfang ZhangCorresponding
Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Zoology
Topics & keywords
- Offspring
- Sperm
- Biology
- Epigenetics
- Phenotype
- Genetics
- Metabolic pathway
- Biogenesis