Cell death induced by endoplasmic reticulum stress

The endoplasmic reticulum is an organelle with multiple functions. The synthesis of transmembrane proteins and proteins that are to be secreted occurs in this organelle. Many conditions that impose stress on cells, including hypoxia, starvation, infections and changes in secretory needs, challenge the folding capacity of the cell and promote endoplasmic reticulum stress. The cellular response involves the activation of sensors that transduce signaling cascades with the aim of restoring homeostasis. This is known as the unfolded protein response, which also intersects with the integrated stress response that reduces protein synthesis through inactivation of the initiation factor eIF2α. Central to the unfolded…

• GD
  Generalitat de Catalunya
• FE
  Federación Española de Enfermedades Raras
• MD
  Ministerio de Economía y Competitividad
• ID
  Instituto de Salud Carlos III

  Award: PI13/00139