The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy

group, the TBI/CTE; McKee, Ann C.; Cairns, Nigel J.; Dickson, Dennis W.; Folkerth, Rebecca D.; Keene, C. Dirk; Litvan, Irene; Perl, Daniel P.; Stein, Thor D.; Vonsattel, Jean-Paul G.; Stewart, William; Tripodis, Yorghos; Crary, John F.; Bieniek, Kevin F.; Dams-O’Connor, Kristen; Alvarez, Victor E.; Gordon, Wayne A.

doi:10.1007/s00401-015-1515-z

articleActa NeuropathologicaDec 14, 2015HYBRID OA

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy

TTthe TBI/CTE groupACAnn C. McKee NJNigel J. Cairns DWDennis W. Dickson RDRebecca D. Folkerth

Boston University · Washington University in St. Louis · +13 more institutions

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Abstract

Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other neurodegenerative conditions, at present, CTE can only be definitively diagnosed by post-mortem examination of brain tissue. As the first part of a series of consensus panels funded by the NINDS/NIBIB to define the neuropathological criteria for CTE, preliminary neuropathological criteria were used by 7 neuropathologists to blindly evaluate 25 cases of various tauopathies, including CTE, Alzheimer's disease, progressive supranuclear palsy, argyrophilic grain disease, corticobasal degeneration, primary age-related tauopathy, and…

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Topics

Keywords

Chronic traumatic encephalopathy
Medicine
Encephalopathy
Pathology
Poison control
Injury prevention
Medical emergency
Psychiatry

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