NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review

The NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells) transcription factor family is a pleiotropic regulator of many cellular signaling pathways, providing a mechanism for the cells in response to a wide variety of stimuli linking to inflammation. The stimulated cells will be regulated by not only the canonical but also non-canonical NF-κB pathways. To initiate both of these pathways, IκB-degradation triggers NF-κB release and the nuclear translocated-heterodimer (or homodimer) can associate with the κB sites of promoter to regulate the gene transcriptions. NF-κB ubiquitously expresses in neurons and the constitutive NF-κB activation is associated with processing of neuronal information. NF-κB…

• DO
  Department of Science and Technology, Ministry of Science and Technology, India

  Award: MOST 104-2320-B-182-010
• CG
  Chang Gung Medical Foundation

  Awards: CMRPD1B0383, CMRPD1C0563, CMRPD1B0332, CMRPD1C0103
• MO
  Ministry of Science and Technology, Taiwan

  Awards: MOST 104-2320-B-182-010, MOST 104