The Genetic Evolution of Melanoma from Precursor Lesions
UCSF Helen Diller Family Comprehensive Cancer Center · University of California, San Francisco · +6 more institutions
Abstract
The pathogenic mutations in melanoma have been largely catalogued; however, the order of their occurrence is not known.
We sequenced 293 cancer-relevant genes in 150 areas of 37 primary melanomas and their adjacent precursor lesions. The histopathological spectrum of these areas included unequivocally benign lesions, intermediate lesions, and intraepidermal or invasive melanomas.
Citation impact
- FWCI
- 45.17
- Percentile
- 100%
- References
- 36
Authors
14- AHA. Hunter ShainCorresponding
UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco
- IYIwei Yeh
University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center
- IKIvanka Kovalyshyn
Cleveland Clinic
- ASAravindhan Sriharan
Orlando Health
- ETEric Talevich
University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center
Topics & keywords
- CDKN2A
- Neuroblastoma RAS viral oncogene homolog
- Melanoma
- PTEN
- GNAQ
- Cancer research
- Genetic heterogeneity
- Mutation
- Good health and well-being