The Macrophage Switch in Obesity Development

Immune cell infiltration in (white) adipose tissue (AT) during obesity is associated with the development of insulin resistance. In AT, the main population of leukocytes are macrophages. Macrophages can be classified into two major populations: M1, classically activated macrophages, and M2, alternatively activated macrophages, although recent studies have identified a broad range of macrophage subsets. During obesity, AT M1 macrophage numbers increase and correlate with AT inflammation and insulin resistance. Upon activation, pro-inflammatory M1 macrophages induce aerobic glycolysis. By contrast, in lean humans and mice, the number of M2 macrophages predominates. M2 macrophages secrete anti-inflammatory…

• IN
  Institut National de la Santé et de la Recherche Médicale
• FD
  Fundação de Amparo à Pesquisa do Estado de São Paulo

  Awards: 15/18121-4, 12/02270-2, 11/15682-4, 12/02270-2, 14/10910-7, 15/18121-4, 11/15682-4
• CN
  Conselho Nacional de Desenvolvimento Científico e Tecnológico