eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences
European Molecular Biology Laboratory · SIB Swiss Institute of Bioinformatics · +12 more institutions
Abstract
EggNOG is a public resource that provides Orthologous Groups (OGs) of proteins at different taxonomic levels, each with integrated and summarized functional annotations. Developments since the latest public release include changes to the algorithm for creating OGs across taxonomic levels, making nested groups hierarchically consistent. This allows for a better propagation of functional terms across nested OGs and led to the novel annotation of 95 890 previously uncharacterized OGs, increasing overall annotation coverage from 67% to 72%. The functional annotations of OGs have been expanded to also provide Gene Ontology terms, KEGG pathways and SMART/Pfam domains for each group. Moreover, eggNOG now provides…
Citation impact
- FWCI
- 65.80
- Percentile
- 100%
- References
- 55
Authors
13- JHJaime Huerta‐CepasCorresponding
European Molecular Biology Laboratory
- DSDamian Szklarczyk
SIB Swiss Institute of Bioinformatics, University of Zurich
- KFKristoffer Forslund
European Molecular Biology Laboratory
- HCHelen Cook
University of Copenhagen, Novo Nordisk Foundation
- DHDavide Heller
SIB Swiss Institute of Bioinformatics, University of Zurich
Topics & keywords
- Biology
- Annotation
- KEGG
- Computational biology
- Upload
- Phylogenetic tree
- Pairwise comparison
- Genome