Sepsis-induced immune dysfunction: can immune therapies reduce mortality?

Sepsis is a systemic inflammatory response induced by an infection, leading to organ dysfunction and mortality. Historically, sepsis-induced organ dysfunction and lethality were attributed to the interplay between inflammatory and antiinflammatory responses. With advances in intensive care management and goal-directed interventions, early sepsis mortality has diminished, only to surge later after "recovery" from acute events, prompting a search for sepsis-induced alterations in immune function. Sepsis is well known to alter innate and adaptive immune responses for sustained periods after clinical "recovery," with immunosuppression being a prominent example of such alterations. Recent studies have centered on…

• AA
  American Association for the Surgery of Trauma
• UO
  University of Michigan

  Award: 48109
• NI
  National Institutes of Health

  Awards: GM-61656, GM-29507
• CO
  College of Pharmacy, University of Michigan
• MS
  Medical School, University of Michigan

  Awards: GM-61656, GM-29507