Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction
Chinese Academy of Sciences · Shanghai Institute of Ceramics · +3 more institutions
Abstract
Metallic glasses and cancer theranostics are emerging fields that do not seem to be related to each other. Herein, we report the facile synthesis of amorphous iron nanoparticles (AFeNPs) and their superior physicochemical properties compared to their crystalline counterpart, iron nanocrystals (FeNCs). The AFeNPs can be used for cancer theranostics by inducing a Fenton reaction in the tumor by taking advantage of the mild acidity and the overproduced H2 O2 in a tumor microenvironment: Ionization of the AFeNPs enables on-demand ferrous ion release in the tumor, and subsequent H2 O2 disproportionation leads to efficient (.)OH generation. The endogenous stimuli-responsive (.)OH generation in the presence AFeNPs…
Citation impact
- FWCI
- 39.04
- Percentile
- 100%
- References
- 36
Authors
10- CZChen Zhang
Chinese Academy of Sciences, Shanghai Institute of Ceramics
- WBWenbo BuCorresponding
Chinese Academy of Sciences, Shanghai Institute of Ceramics
- DNDalong Ni
Chinese Academy of Sciences, Shanghai Institute of Ceramics
- SZShenjian Zhang
Fudan University Shanghai Cancer Center
- QLQing Li
Chinese Academy of Sciences, Shanghai Institute of Ceramics
Topics & keywords
- Ferrous
- Fenton reaction
- Cancer therapy
- Disproportionation
- Materials science
- Nanocrystal
- Cancer
- Amorphous solid
- Affordable and clean energy