Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee
Royal National Orthopaedic Hospital · Research Institute of Radiology · +1 more institution
Abstract
Autologous chondrocyte implantation (ACI) is used widely as a treatment for symptomatic chondral and osteochondral defects of the knee. Variations of the original periosteum-cover technique include the use of porcine-derived type I/type III collagen as a cover (ACI-C) and matrix-induced autologous chondrocyte implantation (MACI) using a collagen bilayer seeded with chondrocytes. We have performed a prospective, randomised comparison of ACI-C and MACI for the treatment of symptomatic chondral defects of the knee in 91 patients, of whom 44 received ACI-C and 47 MACI grafts. Both treatments resulted in improvement of the clinical score after one year. The mean modified Cincinnati knee score increased by 17.6 in…
Citation impact
- FWCI
- 18.09
- Percentile
- 100%
- References
- 31
Authors
7- WBWill BartlettCorresponding
Royal National Orthopaedic Hospital, Research Institute of Radiology, University College London
- JSJohn Skinner
Royal National Orthopaedic Hospital, Research Institute of Radiology, University College London
- CRChristopher R. Gooding
Royal National Orthopaedic Hospital, Research Institute of Radiology, University College London
- RCRichard Carrington
Royal National Orthopaedic Hospital, Research Institute of Radiology, University College London
- AMAdrienne M. Flanagan
Royal National Orthopaedic Hospital, Research Institute of Radiology, University College London
Topics & keywords
- Autologous chondrocyte implantation
- Medicine
- Hyaline cartilage
- Fibrocartilage
- Surgery
- Cartilage
- Chondrocyte
- Periosteum
- Good health and well-being