Non-alcoholic fatty liver disease and diabetes

Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) are common conditions that regularly co-exist and can act synergistically to drive adverse outcomes. The presence of both NAFLD and T2DM increases the likelihood of the development of complications of diabetes (including both macro- and micro- vascular complications) as well as augmenting the risk of more severe NAFLD, including cirrhosis, hepatocellular carcinoma and death. The mainstay of NAFLD management is currently to reduce modifiable metabolic risk. Achieving good glycaemic control and optimising weight loss are pivotal to restricting disease progression. Once cirrhosis has developed, it is necessary to screen for complications and…

• W
  Wellcome

  Award: 104458/Z/14/Z
• WT
  Wellcome Trust
• IE
  Irish Endocrine Society
• NI
  National Institute for Health and Care Research
• NO
  NIHR Oxford Biomedical Research Centre