Early infancy microbial and metabolic alterations affect risk of childhood asthma
University of British Columbia · Canada's Michael Smith Genome Sciences Centre · +7 more institutions
Abstract
Asthma is the most prevalent pediatric chronic disease and affects more than 300 million people worldwide. Recent evidence in mice has identified a "critical window" early in life where gut microbial changes (dysbiosis) are most influential in experimental asthma. However, current research has yet to establish whether these changes precede or are involved in human asthma. We compared the gut microbiota of 319 subjects enrolled in the Canadian Healthy Infant Longitudinal Development (CHILD) Study, and show that infants at risk of asthma exhibited transient gut microbial dysbiosis during the first 100 days of life. The relative abundance of the bacterial genera Lachnospira, Veillonella, Faecalibacterium, and…
Citation impact
- FWCI
- 219.88
- Percentile
- 100%
- References
- 67
Authors
20- MAMarie‐Claire ArrietaCorresponding
University of British Columbia, Canada's Michael Smith Genome Sciences Centre
- LTLeah T. StiemsmaCorresponding
University of British Columbia, BC Children's Hospital, Child and Family Research Institute
- PAPedro A. Dimitriu
University of British Columbia
- LTLisa Thorson
University of British Columbia, Canada's Michael Smith Genome Sciences Centre
- SRShannon Russell
University of British Columbia, Canada's Michael Smith Genome Sciences Centre
Topics & keywords
- Affect (linguistics)
- Asthma
- Medicine
- Environmental health
- Physiology
- Intensive care medicine
- Immunology
- Psychology
- Good health and well-being