ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer
The University of Sydney · Centenary Institute · +6 more institutions
Abstract
Alanine, serine, cysteine-preferring transporter 2 (ASCT2; SLC1A5) mediates uptake of glutamine, a conditionally essential amino acid in rapidly proliferating tumour cells. Uptake of glutamine and subsequent glutaminolysis is critical for activation of the mTORC1 nutrient-sensing pathway, which regulates cell growth and protein translation in cancer cells. This is of particular interest in breast cancer, as glutamine dependence is increased in high-risk breast cancer subtypes. Pharmacological inhibitors of ASCT2-mediated transport significantly reduced glutamine uptake in human breast cancer cell lines, leading to the suppression of mTORC1 signalling, cell growth and cell cycle progression. Notably, these…
Citation impact
- FWCI
- 23.18
- Percentile
- 100%
- References
- 53
Authors
16- MVMichelle van GeldermalsenCorresponding
The University of Sydney, Centenary Institute
- QWQian Wang
The University of Sydney, Centenary Institute
- RNRajini Nagarajah
The University of Sydney, Centenary Institute
- ADAmy D. Marshall
The University of Sydney, Centenary Institute
- ATAnnora Thoeng
The University of Sydney, Centenary Institute
Topics & keywords
- Glutamine
- Cancer research
- Glutaminolysis
- Biology
- Breast cancer
- Cell growth
- Cancer cell
- mTORC1
- Good health and well-being