articleNature BiotechnologyJan 18, 2016Closed access

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

JGJohn G. DoenchNFNicolò FusiMEMeagan E. SullenderMHMudra HegdeEWEmma W Vaimberg

Broad Institute · Microsoft (United States) · +3 more institutions

PubMed
Indexed incrossrefpubmed

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4,939
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162.24
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100%
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54
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Authors

13

Topics & keywords

Topics
Keywords
  • CRISPR
  • Cas9
  • Subgenomic mRNA
  • Genome editing
  • Guide RNA
  • Computer science
  • Computational biology
  • Genome engineering
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