Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects
Rutgers, The State University of New Jersey · KU Leuven
Abstract
1,25-Dihydroxvitamin D3 [1,25(OH)2D3] is the hormonally active form of vitamin D. The genomic mechanism of 1,25(OH)2D3 action involves the direct binding of the 1,25(OH)2D3 activated vitamin D receptor/retinoic X receptor (VDR/RXR) heterodimeric complex to specific DNA sequences. Numerous VDR co-regulatory proteins have been identified, and genome-wide studies have shown that the actions of 1,25(OH)2D3 involve regulation of gene activity at a range of locations many kilobases from the transcription start site. The structure of the liganded VDR/RXR complex was recently characterized using cryoelectron microscopy, X-ray scattering, and hydrogen deuterium exchange. These recent technological advances will result…
Citation impact
- FWCI
- 68.82
- Percentile
- 100%
- References
- 544
Authors
5- SCSylvia ChristakosCorresponding
Rutgers, The State University of New Jersey, KU Leuven
- PDPuneet Dhawan
Rutgers, The State University of New Jersey, KU Leuven
- AVAnnemieke Verstuyf
Rutgers, The State University of New Jersey, KU Leuven
- LVLieve Verlinden
Rutgers, The State University of New Jersey, KU Leuven
- GCGeert Carmeliet
Rutgers, The State University of New Jersey, KU Leuven
Topics & keywords
- Mechanism (biology)
- Mechanism of action
- Biology
- Metabolism
- Action (physics)
- Chemistry
- Biochemistry
- Good health and well-being