Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease
Inserm · AgroParisTech · +28 more institutions
Abstract
Objective There is substantial inter-individual diversity in the susceptibility of alcoholics to liver injury. Alterations of intestinal microbiota (IM) have been reported in alcoholic liver disease (ALD), but the extent to which they are merely a consequence or a cause is unknown. We aimed to demonstrate that a specific dysbiosis contributes to the development of alcoholic hepatitis (AH). Design We humanised germ-free and conventional mice using human IM transplant from alcoholic patients with or without AH. The consequences on alcohol-fed recipient mice were studied. Results A specific dysbiosis was associated with ALD severity in patients. Mice harbouring the IM from a patient with severe AH (sAH) developed…
Citation impact
- FWCI
- 15.36
- Percentile
- 100%
- References
- 35
Authors
24- MLMarta Llopis
Inserm, AgroParisTech, Microbiologie de l’alimentation au service de la santé, Inflammation, Microbiome and Immunosurveillance, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique
- ACAnne‐Marie Cassard
Inserm, Université Paris-Saclay, Institut thématique Immunologie, inflammation, infectiologie et microbiologie, Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine, Inflammation, Microbiome and Immunosurveillance, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique
- LWLaura Wrzosek
Inserm, Inflammation, Microbiome and Immunosurveillance, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique
- LBLaura Boschat
AgroParisTech, Microbiologie de l’alimentation au service de la santé
- ABAurélia Bruneau
AgroParisTech, Microbiologie de l’alimentation au service de la santé
Topics & keywords
- Dysbiosis
- Alcoholic liver disease
- Immunology
- Liver injury
- Mesenteric lymph nodes
- Natural killer T cell
- Gut flora
- Medicine
- Good health and well-being