Fungal microbiota dysbiosis in IBD
Inserm · AgroParisTech · +15 more institutions
Abstract
The bacterial intestinal microbiota plays major roles in human physiology and IBDs. Although some data suggest a role of the fungal microbiota in IBD pathogenesis, the available data are scarce. The aim of our study was to characterise the faecal fungal microbiota in patients with IBD.
Bacterial and fungal composition of the faecal microbiota of 235 patients with IBD and 38 healthy subjects (HS) was determined using 16S and ITS2 sequencing, respectively. The obtained sequences were analysed using the Qiime pipeline to assess composition and diversity. Bacterial and fungal taxa associated with clinical parameters were identified using multivariate association with linear models. Correlation between bacterial and fungal microbiota was investigated using Spearman's test and distance correlation.
Citation impact
- FWCI
- 48.39
- Percentile
- 100%
- References
- 47
Authors
16- HSHarry SokolCorresponding
Inserm, AgroParisTech, Université Paris-Saclay, Microbiologie de l’alimentation au service de la santé, Sorbonne Université, Institut thématique Immunologie, inflammation, infectiologie et microbiologie, Assistance Publique – Hôpitaux de Paris, Hôpital Saint-Antoine, Centre de Recherche Saint-Antoine
- VLValentin Leducq
Inserm, Sorbonne Université, Institut thématique Immunologie, inflammation, infectiologie et microbiologie, Assistance Publique – Hôpitaux de Paris, Hôpital Saint-Antoine, Centre de Recherche Saint-Antoine
- HAHugues Aschard
Harvard University
- HPHang‐Phuong Pham
Sorbonne Université, Laboratoire de Probabilités et Modèles Aléatoires, Iltoo Pharma (France)
- SJSarah Jégou
Inserm, Sorbonne Université, Institut thématique Immunologie, inflammation, infectiologie et microbiologie, Assistance Publique – Hôpitaux de Paris, Centre de Recherche Saint-Antoine, Laboratoire de Mécanique et Procédés de Fabrication
Topics & keywords
- Dysbiosis
- Biology
- Microbiology
- Gut flora
- Pathogenesis
- Inflammatory bowel disease
- Immunology
- Disease
- Life in Land