Gut mucosal microbiome across stages of colorectal carcinogenesis

Gut microbial dysbiosis contributes to the development of colorectal cancer (CRC). Here we catalogue the microbial communities in human gut mucosae at different stages of colorectal tumorigenesis. We analyse the gut mucosal microbiome of 47 paired samples of adenoma and adenoma-adjacent mucosae, 52 paired samples of carcinoma and carcinoma-adjacent mucosae and 61 healthy controls. Probabilistic partitioning of relative abundance profiles reveals that a metacommunity predominated by members of the oral microbiome is primarily associated with CRC. Analysis of paired samples shows differences in community configurations between lesions and the adjacent mucosae. Correlations of bacterial taxa indicate early signs…

• CF
  Croucher Foundation
• NN
  National Natural Science Foundation of China

  Awards: 2012AA02A506, 81272194
• CU
  Chinese University of Hong Kong
• SV
  Shenzhen Virtual University Park
• SR
  Shenzhen Research Institute, City University of Hong Kong
• NH
  National High-tech Research and Development Program
• NK
  National Key Research and Development Program of China

  Award: 2013CB531401