Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters
Johns Hopkins University · Johns Hopkins Medicine · +1 more institution
Abstract
Recent genomic studies challenge the conventional model that each metastasis must arise from a single tumor cell and instead reveal that metastases can be composed of multiple genetically distinct clones. These intriguing observations raise the question: How do polyclonal metastases emerge from the primary tumor? In this study, we used multicolor lineage tracing to demonstrate that polyclonal seeding by cell clusters is a frequent mechanism in a common mouse model of breast cancer, accounting for >90% of metastases. We directly observed multicolored tumor cell clusters across major stages of metastasis, including collective invasion, local dissemination, intravascular emboli, circulating tumor cell clusters,…
Citation impact
- FWCI
- 38.36
- Percentile
- 100%
- References
- 55
Authors
11- KJKevin J. CheungCorresponding
Johns Hopkins University, Johns Hopkins Medicine, Fred Hutch Cancer Center
- VPVeena Padmanaban
Johns Hopkins University, Johns Hopkins Medicine
- VLVanesa L. Silvestri
Johns Hopkins University, Johns Hopkins Medicine
- KSKoen Schipper
Johns Hopkins University, Johns Hopkins Medicine
- JDJoshua D. Cohen
Johns Hopkins University, Johns Hopkins Medicine
Topics & keywords
- Biology
- Metastasis
- Epiregulin
- Tenascin C
- Cancer research
- Circulating tumor cell
- Keratin 14
- Cytokeratin
- Good health and well-being