Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives

Collagen is the main structural protein of most hard and soft tissues in animals and the human body, which plays an important role in maintaining the biological and structural integrity of the extracellular matrix (ECM) and provides physical support to tissues. Collagen can be extracted and purified from a variety of sources and offers low immunogenicity, a porous structure, good permeability, biocompatibility and biodegradability. Collagen scaffolds have been widely used in tissue engineering due to these excellent properties. However, the poor mechanical property of collagen scaffolds limits their applications to some extent. To overcome this shortcoming, collagen scaffolds can be cross-linked by chemical or…

• NN
  National Natural Science Foundation of China

  Award: 11172338
• FR
  Fundamental Research Funds for the Central Universities

  Award: CQDXWL-2012-Z001