Long-term neural and physiological phenotyping of a single human

Psychiatric disorders are characterized by major fluctuations in psychological function over the course of weeks and months, but the dynamic characteristics of brain function over this timescale in healthy individuals are unknown. Here, as a proof of concept to address this question, we present the MyConnectome project. An intensive phenome-wide assessment of a single human was performed over a period of 18 months, including functional and structural brain connectivity using magnetic resonance imaging, psychological function and physical health, gene expression and metabolomics. A reproducible analysis workflow is provided, along with open access to the data and an online browser for results. We demonstrate…

• NS
  National Science Foundation

  Awards: 1131441, 1237975
• JS
  James S. McDonnell Foundation
• CP
  Cancer Prevention and Research Institute of Texas
• TE
  Texas Emerging Technology Fund
• UO
  University of Texas at Austin
• NO
  Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Awards: 639.072.411, VIDI Grant 639.072.411
• NI
  National Institutes of Health

  Awards: MH100872, MH083824, F1515
• MR
  Medical Research Council
• NH
  National Health and Medical Research Council

  Award: GNT1072403