Protein Structure and Function Prediction Using I‐TASSER
Nankai University · University of Michigan
Abstract
I-TASSER is a hierarchical protocol for automated protein structure prediction and structure-based function annotation. Starting from the amino acid sequence of target proteins, I-TASSER first generates full-length atomic structural models from multiple threading alignments and iterative structural assembly simulations followed by atomic-level structure refinement. The biological functions of the protein, including ligand-binding sites, enzyme commission number, and gene ontology terms, are then inferred from known protein function databases based on sequence and structure profile comparisons. I-TASSER is freely available as both an on-line server and a stand-alone package. This unit describes how to use the…
Citation impact
- FWCI
- 9.94
- Percentile
- 100%
- References
- 58
Authors
2Topics & keywords
- Threading (protein sequence)
- Protein structure prediction
- Computer science
- Protein structure
- Protein function prediction
- Computational biology
- Protein Data Bank (RCSB PDB)
- Function (biology)