Brain-derived neurotrophic factor and its clinical implications
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Abstract
Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is essential for learning and memory. It is widely expressed in the CNS, gut and other tissues. BDNF binds to its high affinity receptor TrkB (tyrosine kinase B) and activates signal transduction cascades (IRS1/2, PI3K, Akt), crucial for CREB and CBP production, that encode proteins involved in β cell survival. BDNF and insulin-like growth factor-1 have similar downstream signaling mechanisms incorporating both p-CAMK and MAPK that increase the expression of pro-survival genes. Brain-derived neurotrophic factor regulates glucose…
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1,308
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Authors
2Topics & keywords
Topics
Keywords
- Tropomyosin receptor kinase B
- Neurotrophic factors
- CREB
- Medicine
- Brain-derived neurotrophic factor
- Neurotrophin
- Insulin-like growth factor
- Neuroscience
UN Sustainable Development Goals
- Good health and well-being
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