Targeting senescent cells enhances adipogenesis and metabolic function in old age
Mayo Clinic in Florida · University of California, Berkeley
Abstract
Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy. Here we show that primary human senescent fat progenitors secrete activin A and directly inhibit adipogenesis in non-senescent progenitors. Blocking activin A partially restored lipid accumulation and expression of key adipogenic markers in differentiating progenitors exposed to senescent cells. Mouse fat tissue activin A increased with aging. Clearing senescent cells from 18-month-old naturally-aged INK-ATTAC mice reduced circulating activin A, blunted fat loss, and enhanced adipogenic transcription factor expression within 3 weeks. JAK inhibitor…
Citation impact
- FWCI
- 22.14
- Percentile
- 100%
- References
- 69
Authors
14- MXMing Xu
Mayo Clinic in Florida, University of California, Berkeley
- AKAllyson K. Palmer
Mayo Clinic in Florida, University of California, Berkeley
- HDHusheng Ding
Mayo Clinic in Florida, University of California, Berkeley
- MWMegan Weivoda
Mayo Clinic in Florida, University of California, Berkeley
- TPTamar Pirtskhalava
Mayo Clinic in Florida, University of California, Berkeley
Topics & keywords
- Adipogenesis
- Endocrinology
- Internal medicine
- Progenitor cell
- Adipose tissue
- Biology
- Adipocyte
- Lipotoxicity