Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
University of Parma · University of Washington
Abstract
Increasing interest has recently focused on determining whether several natural compounds, collectively referred to as nutraceuticals, may exert neuroprotective actions in the developing, adult, and aging nervous system. Quercetin, a polyphenol widely present in nature, has received the most attention in this regard. Several studies in vitro, in experimental animals and in humans, have provided supportive evidence for neuroprotective effects of quercetin, either against neurotoxic chemicals or in various models of neuronal injury and neurodegenerative diseases. The exact mechanisms of such protective effects remain elusive, though many hypotheses have been formulated. In addition to a possible direct…
Citation impact
- FWCI
- 17.16
- Percentile
- 100%
- References
- 114
Authors
4Topics & keywords
- Neuroprotection
- Oxidative stress
- Quercetin
- Oxidative damage
- Chemistry
- Pharmacology
- Neuroscience
- Biology