Animal models of osteoarthritis: classification, update, and measurement of outcomes

Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world today. It is a debilitating chronic illness causing pain and immense discomfort to the affected individual. Significant research is currently ongoing to understand its pathophysiology and develop successful treatment regimens based on this knowledge. Animal models have played a key role in achieving this goal. Animal models currently used to study osteoarthritis can be classified based on the etiology under investigation, primary osteoarthritis, and post-traumatic osteoarthritis, to better clarify the relationship between these models and the pathogenesis of the disease. Non-invasive animal models have shown significant…

• NS
  National Science Foundation
• NI
  National Institutes of Health

  Awards: NIH DP1 AR068147, DP1 AR068147, R01 AR063698, NIH R01