Comprehensive genomic characterization of squamous cell lung cancers

Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no molecularly targeted agents have been specifically developed for its treatment. As part of The Cancer Genome Atlas, here we profile 178 lung squamous cell carcinomas to provide a comprehensive landscape of genomic and epigenomic alterations. We show that the tumour type is characterized by complex genomic alterations, with a mean of 360 exonic mutations, 165 genomic rearrangements, and 323 segments of copy number alteration per tumour. We find statistically recurrent mutations in 11 genes,…

• NI
  National Institutes of Health

  Awards: U24 CA143882, U54 HG003079, U24 CA143866, U54 HG003067, U24 CA143799, CA143835, U24 CA143835, U24 CA143843, U24 CA144025, HG003079, U54 HG003273, CA143883, U24 CA143845, U24 CA143848, U24 CA143858, HG003067, U24 CA143883, U24 CA143840, U24 CA143867
• BC
  BC Cancer Agency
• NH
  National Human Genome Research Institute

  Awards: U54 HG003273, U54 HG003079, HG003067, HG003079, HG003273, U54 HG003067
• NC
  National Cancer Institute

  Awards: U24 CA143799, U24 CA143835, U24 CA143867, U54 HG003273, U54 HG003067, U24 CA143866, U24 CA143845, CA143883, U24 CA143883, U24 CA143848, U24 CA143858, U24 CA144025, U24 CA143843, U24 CA143840, CA143840, U24 CA143882, U54 HG003079