articleThe Journal of Clinical Endocrinology & MetabolismFeb 22, 2016BRONZE OA

Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study

VRVanita R. ArodaSLSharon L. EdelsteinRGRonald GoldbergWCWilliam C. KnowlerSMSantica M. Marcovina

MedStar Health · George Washington University · +9 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Objective

To assess the risk of B12 deficiency with metformin use in the Diabetes Prevention Program (DPP)/DPP Outcomes Study (DPPOS).

Design

Secondary analysis from the DPP/DPPOS. Participants were assigned to the placebo group (PLA) (n = 1082) or the metformin group (MET) (n = 1073) for 3.2 years; subjects in the metformin group received open-label metformin for an additional 9 years.

Citation impact

514
total citations
FWCI
33.24
Percentile
100%
References
43
Citations per year

Authors

11

Topics & keywords

Topics
Keywords
  • Metformin
  • Medicine
  • Vitamin B12
  • Internal medicine
  • Diabetes mellitus
  • Odds ratio
  • Context (archaeology)
  • Overweight
UN Sustainable Development Goals
  • Good health and well-being
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