deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution
The Honourable Society of Lincoln's Inn · CRUK Lung Cancer Centre of Excellence · +4 more institutions
Abstract
Analysis of somatic mutations provides insight into the mutational processes that have shaped the cancer genome, but such analysis currently requires large cohorts. We develop deconstructSigs, which allows the identification of mutational signatures within a single tumor sample.
Application of deconstructSigs identifies samples with DNA repair deficiencies and reveals distinct and dynamic mutational processes molding the cancer genome in esophageal adenocarcinoma compared to squamous cell carcinomas.
Citation impact
- FWCI
- 41.57
- Percentile
- 100%
- References
- 9
Authors
5- RRRachel Rosenthal
The Honourable Society of Lincoln's Inn, CRUK Lung Cancer Centre of Excellence, University College London, The Francis Crick Institute
- NMNicholas McGranahan
CRUK Lung Cancer Centre of Excellence, The Honourable Society of Lincoln's Inn, University College London, The Francis Crick Institute
- JHJavier Herrero
CRUK Lung Cancer Centre of Excellence, University College London
- BSBarry S. TaylorCorresponding
Molecular Oncology (United States), Memorial Sloan Kettering Cancer Center
- CSCharles Swanton
The Francis Crick Institute, The Honourable Society of Lincoln's Inn, University College London, CRUK Lung Cancer Centre of Excellence
Topics & keywords
- Biology
- Genetics
- Human genetics
- Evolutionary biology
- Computational biology
- DNA
- DNA repair
- Gene
- Life in Land