Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication

Emerging evidence indicates that disruption of the gut microbial community (dysbiosis) impairs mental health. Germ-free mice and antibiotic-induced gut dysbiosis are two approaches to establish causality in gut microbiota-brain relationships. However, both models have limitations, as germ-free mice display alterations in blood-brain barrier and brain ultrastructure and antibiotics may act directly on the brain. We hypothesized that the concerns related to antibiotic-induced gut dysbiosis can only adequately be addressed if the effect of intragastric treatment of adult mice with multiple antibiotics on (i) gut microbial community, (ii) metabolite profile in the colon, (iii) circulating metabolites, (iv)…

• AS
  Austrian Science Fund

  Awards: W1241-B18, P25912-B23
• BF
  Bundesministerium für Wissenschaft, Forschung und Wirtschaft
• BF
  Bundesministerium für Verkehr, Innovation und Technologie
• SW
  Steirische Wirtschaftsförderungsgesellschaft
• MU
  Medizinische Universität Graz