Understanding cachexia as a cancer metabolism syndrome

Metabolic reprogramming occurs in tumors to foster cancer cell proliferation, survival and metastasis, but as well at a systemic level affecting the whole organism, eventually leading to cancer cachexia. Indeed, as cancer cells rely on external sources of nitrogen and carbon skeleton to grow, systemic metabolic deregulation promoting tissue wasting and metabolites mobilization ultimately supports tumor growth. Cachectic patients experience a wide range of symptoms affecting several organ functions such as muscle, liver, brain, immune system and heart, collectively decreasing patients' quality of life and worsening their prognosis. Moreover, cachexia is estimated to be the direct cause of at least 20% of cancer…

• FL
  Fondation Louvain
• FD
  Fonds De La Recherche Scientifique - FNRS
• BF
  Belgian Federal Science Policy Office

  Awards: Attraction Pole (IAP) grant #UP7-03, UP7-03
• FW
  Fédération Wallonie-Bruxelles

  Award: ARC 14/19-058
• S
  Servier