articleJournal of Clinical InvestigationFeb 14, 2016BRONZE OA

Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers

ILIñigo LandaTITihana IbrahimpašićLBLaura BoucaiRSRileen SinhaJAJeffrey A. Knauf

Memorial Sloan Kettering Cancer Center · Icahn School of Medicine at Mount Sinai · +2 more institutions

PubMed
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Abstract

Background

Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) are rare and frequently lethal tumors that so far have not been subjected to comprehensive genetic characterization.

Methods

We performed next-generation sequencing of 341 cancer genes from 117 patient-derived PDTCs and ATCs and analyzed the transcriptome of a representative subset of 37 tumors. Results were analyzed in the context of The Cancer Genome Atlas study (TCGA study) of papillary thyroid cancers (PTC).

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1,266
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80.67
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100%
References
67
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Authors

17

Topics & keywords

Topics
Keywords
  • Cancer research
  • HRAS
  • Biology
  • Thyroid cancer
  • Anaplastic thyroid cancer
  • Carcinogenesis
  • Transcriptome
  • Cancer
UN Sustainable Development Goals
  • Good health and well-being
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Funding