Targeting the CCL2-CCR2 signaling axis in cancer metastasis
University of Oxford · CRUK/MRC Oxford Institute for Radiation Oncology
Abstract
// Su Yin Lim 1 , Arseniy E. Yuzhalin 1 , Alex N. Gordon-Weeks 1 and Ruth J. Muschel 1 1 CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom Correspondence to: Su Yin Lim, email: // Keywords : chemokines, cancer metastasis, cancer therapy, clinical trials Received : October 26, 2015 Accepted : January 31, 2016 Published : February 14, 2016 Abstract The CCL2-CCR2 signaling axis has generated increasing interest in recent years due to its association with the progression of cancer. Although first described as a chemotactic molecule with physiological roles in regulating inflammation, recent studies have revealed a pro-tumorigenic function for CCL2 in favoring cancer…
Citation impact
- FWCI
- 18.24
- Percentile
- 100%
- References
- 117
Authors
4- SYSu Yin LimCorresponding
University of Oxford, CRUK/MRC Oxford Institute for Radiation Oncology
- AEArseniy E. Yuzhalin
University of Oxford, CRUK/MRC Oxford Institute for Radiation Oncology
- AGAlex Gordon‐Weeks
University of Oxford, CRUK/MRC Oxford Institute for Radiation Oncology
- RJRuth J. Muschel
University of Oxford, CRUK/MRC Oxford Institute for Radiation Oncology
Topics & keywords
- CCR2
- Metastasis
- CCL2
- Cancer research
- Cancer
- Medicine
- Stromal cell
- Angiogenesis
- Good health and well-being