Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab
University of Tübingen · Dutch Cancer Society · +17 more institutions
Abstract
PURPOSE: To identify baseline peripheral blood biomarkers associated with clinical outcome following ipilimumab treatment in advanced melanoma patients. EXPERIMENTAL DESIGN: Frequencies of myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg), serum lactate dehydrogenase (LDH), routine blood counts, and clinical characteristics were assessed in 209 patients. Endpoints were overall survival (OS) and best overall response. Statistical calculations were done by Kaplan-Meier and Cox regression analysis, including calibration and discrimination by C-statistics. RESULTS: Low baseline LDH, absolute monocyte counts (AMC), Lin(-)CD14(+)HLA-DR(-/low)-MDSC frequencies, and high absolute eosinophil counts…
Citation impact
- FWCI
- 35.19
- Percentile
- 100%
- References
- 57
Authors
24- AMAlexander Martens
University of Tübingen
- KWKilian Wistuba‐Hamprecht
University of Tübingen
- MGMarnix Geukes Foppen
Dutch Cancer Society, Oncode Institute
- JYJianda Yuan
Memorial Sloan Kettering Cancer Center, Kettering University
- MAMichael A. Postow
Memorial Sloan Kettering Cancer Center, Cornell University, Kettering University
Topics & keywords
- Ipilimumab
- Medicine
- Oncology
- Melanoma
- Internal medicine
- Peripheral blood
- Clinical trial
- Biomarker
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