Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
Rutgers, The State University of New Jersey · Rutgers New Jersey Medical School · +10 more institutions
Abstract
Apoptosis is an evolutionarily conserved and tightly regulated cell death modality. It serves important roles in physiology by sculpting complex tissues during embryogenesis and by removing effete cells that have reached advanced age or whose genomes have been irreparably damaged. Apoptosis culminates in the rapid and decisive removal of cell corpses by efferocytosis, a term used to distinguish the engulfment of apoptotic cells from other phagocytic processes. Over the past decades, the molecular and cell biological events associated with efferocytosis have been rigorously studied, and many eat-me signals and receptors have been identified. The externalization of phosphatidylserine (PS) is arguably the most…
Citation impact
- FWCI
- 24.91
- Percentile
- 100%
- References
- 139
Authors
16- RBRaymond B. BirgeCorresponding
Rutgers, The State University of New Jersey, Rutgers New Jersey Medical School
- SBSebastian BoeltzCorresponding
Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen
- SKSushil Kumar
Rutgers, The State University of New Jersey, Rutgers New Jersey Medical School
- JWJay W. Carlson
Avid Bioservices (United States)
- JLJoão Luiz Mendes Wanderley
Universidade Federal do Rio de Janeiro
Topics & keywords
- Efferocytosis
- Biology
- Cancer
- Cell biology
- Apoptosis
- Innate immune system
- Immune system
- Immunology
- Good health and well-being